Primary hyperparathyroidism (PHPT), a condition that is diagnosed in about 100,000 Americans per year, holds this distinction.

You remember the old mnemonic: “Bones, stones, abdominal groans, and psychic moans.” Routine and widespread checking of chemistry panels has largely rendered the above constellation of symptoms a historic relic, as the vast majority of patients with PHPT are asymptomatic at diagnosis. Yet, if present, the clinical manifestations can be protean.